Arsenal and Chelsea avoided a London derby in the Europa League quarter-finals with The Gunners battling Napoli, while The Blues take on Slavia Prague.
The fixtures also feature a Spanish derby with Villarreal facing Valencia while Portuguese team Benfica will play Germany’s Eintracht Frankfurt.
The first legs will be played on Thursday 11 April with the second legs on 18 April.
Arsenal boss Unai Emery is chasing a fourth Europa League title as manager after winning the competition three successive times at Sevilla.
Arsenal and Chelsea will only face off if they meet in the final, while Maurizio Sarri will only clash with his former club if they both make it to the final.