Anthony Martial and Jesse Lingard have been ruled out for two to three weeks and will miss Manchester United’s games against Chelsea and Liverpool.
Lingard pulled up shortly before half-time in the first leg of the last-16 tie against Paris Saint-Germain at Old Trafford with what appeared to be a hamstring injury.
Martial was injured earlier in the game and played on until the interval but did not reappear for the second half.
“I think they will be out for two to three weeks looking at it now,” Solskjaer said in his press conference ahead of the FA Cup fifth-round tie with Chelsea.
A three-week absence would see both players miss the Premier League game at home to Liverpool next Sunday, and could even see both sit out the return leg against PSG on March 6.
Solskjaer says Alexis Sanchez and Romelu Lukaku, alongside some of United’s younger prospects, will get a chance to prove their worth during Lingard and Martial’s spell out.
He said: “It is a chance for anyone who plays, whether it is Alexis, Romelu or Angel (Gomes).
“Anthony and Jesse have done really well for us, they are vital in the attacking parts with their pace.
“Romelu and Alexis have different skill sets, so we just need to gel a team together for Monday now.”
The caretaker United boss was hoping to involve 17-year-old Mason Greenwood in the squad to face Chelsea but revealed the youngster has also been struck with an injury blow.